LIGHT (Animal Free)

• Description:

  LIGHT belongs to the TNF family of ligands, and can signal through the herpes virus entry mediator type A receptor (HVEM, TNFRSF14), LTβR, or bind to a decoy receptor, DcR3. It is expressed in splenocytes, activated PBL, CD8+ tumor infiltrating lymphocytes, granulocytes, and monocytes. LIGHT has the ability to activate NF-κB, to co-stimulate the activation of lymphocytes and to induce apoptosis in certain human tumor cells. Recombinant Murine LIGHT is a 20.1 kDa protein containing 183 amino acid residues, comprising the TNF-homologous region of the LIGHT extracellular domain.

• Synonyms:

  Tnfsf14; LTg; HVEML; LIGHT; Ly113; HVEM-L; LIGHT; tumor necrosis factor (ligand) superfamily, member 14

• NCBI Gene ID:

  50930

• UniProt:

  Q9QYH9

• Accession Number:

  NP_062291

• Accession Number mRNA:

  NM_019418

• Chromosomal Location:

  17; 17 D-E1

• Reactivity:

  Mouse

• Cross Reactivity:

  Human, Mouse

• Sequence:

  MRLHQRLGDI VAHLPDGGKG SWEKLIQDQR SHQANPAAHL TGANASLIGI GGPLLWETRL GLAFLRGLTY HDGALVTMEP GYYYVYSKVQ LSGVGCPQGL ANGLPITHGL YKRTSRYPKE LELLVSRRSP CGRANSSRVW WDSSFLGGVV HLEAGEEVVV RVPGNRLVRP RDGTRSYFGA FMV

• Endotoxin:

  < 0.01 ng/µg of protein (< 0.1 EU/µg)

• Purity:

  ≥ 98% by SDS-PAGE gel and HPLC analyses.

• Bioactivity:

  Not available.

• Length:

  183

• Form:

  Lyophilized

• Molecular Weight:

  20.1 kDa

• Host or Source:

  E. coli