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LIGHT (Animal Free)

CAT: 0209-M10-076-L1000-AFSize: 1000 µgDry Ice: NoHazardous: No
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CAT#:0209-M10-076-L1000-AFSize:1000 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LIGHT belongs to the TNF family of ligands, and can signal through the herpes virus entry mediator type A receptor (HVEM, TNFRSF14), LTβR, or bind to a decoy receptor, DcR3. It is expressed in splenocytes, activated PBL, CD8+ tumor infiltrating lymphocytes, granulocytes, and monocytes. LIGHT has the ability to activate NF-κB, to co-stimulate the activation of lymphocytes and to induce apoptosis in certain human tumor cells. Recombinant Murine LIGHT is a 20.1 kDa protein containing 183 amino acid residues, comprising the TNF-homologous region of the LIGHT extracellular domain.
Synonyms
Tnfsf14; LTg; HVEML; LIGHT; Ly113; HVEM-L; LIGHT; tumor necrosis factor (ligand) superfamily, member 14
NCBI Gene ID
50930
UniProt
Q9QYH9
Accession Number
NP_062291
Accession Number mRNA
NM_019418
Chromosomal Location
17; 17 D-E1
Reactivity
Mouse
Cross Reactivity
Human, Mouse
Sequence
MRLHQRLGDI VAHLPDGGKG SWEKLIQDQR SHQANPAAHL TGANASLIGI GGPLLWETRL GLAFLRGLTY HDGALVTMEP GYYYVYSKVQ LSGVGCPQGL ANGLPITHGL YKRTSRYPKE LELLVSRRSP CGRANSSRVW WDSSFLGGVV HLEAGEEVVV RVPGNRLVRP RDGTRSYFGA FMV
Endotoxin
< 0.01 ng/µg of protein (< 0.1 EU/µg)
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Bioactivity
Not available.
Length
183
Form
Lyophilized
Molecular Weight
20.1 kDa
Host or Source
E. coli

UniProtKB · Q9QYH9

Tumor necrosis factor ligand superfamily member 14

TNF14_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q9QYH9
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Tnfsf14
Protein existence
2: Evidence at transcript level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q059Y9
Protein keywords

Cellular component

Cell membraneMembraneSecreted

Molecular function

Cytokine

PTM

Disulfide bondGlycoprotein

Technical term

Reference proteome

Domain

Signal-anchorTransmembraneTransmembrane helix

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MBS692852-01Mouse LIGHT (Animal Free)
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