Animal-Free LIGHT/TNFSF14, Human (His)

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Dry Ice Shipment: No

Alternative Products

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M10-076-AF	LIGHT (Animal Free) Recombinant Protein
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UA040352-P-05	LIGHT/TNFSF14 Protein, Human
UA040352-P-01	LIGHT/TNFSF14 Protein, Human
UA040352-P-02	LIGHT/TNFSF14 Protein, Human
UA040352-P-03	LIGHT/TNFSF14 Protein, Human
UA040352-P-04	LIGHT/TNFSF14 Protein, Human
UA040352-P-06	LIGHT/TNFSF14 Protein, Human
RQ7564	Light Antibody / Tnfsf14
E42EH-235	Human LIGHT / TNFSF14 ELISA KIT

CAT:

804-HY-P700136AF-03

Size:

10 µg

Price:

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For price, please contact [email protected].

Animal-Free LIGHT/TNFSF14, Human (His)

UNSPSC Description: LIGHT/TNFSF14 protein (CD258; TNFRSF14) is a type II transmembrane protein produced by activated T cells. It is a TNFRSF14/HVEM ligand and belongs to the tumor necrosis factor (TNF) family. LIGHT/TNFSF14 is mainly expressed in spleen, with two subtypes: membrane-bound type and soluble type [1]. LIGHT/TNFSF14 protein can be used as immune checkpoint molecule of tumor, and stimulate natural killer cells to produce interferon TFNγ, triggering tumor apoptosis signal [2]. LIGHT/TNFSF14 is also involved in the dominant LTβR-NIK-p52 NF-κB pathway promoting the expression of inflammatory gene[3]. In addition, LIGHT/TNFSF14 protein is a co-stimulatory factor that activates lymphoid cells and has an inhibitory effect on herpes virus infection[4]. Human LIGHT/TNFSF14 Protein has 240 amino acids and a transmembrane domain (38-58 a.a.). Animal-Free LIGHT/TNFSF14 Protein, Human (His) is the extracellular part (R64-V240) of human LIGHT/TNFSF14 Protein, produced by E. coli, with C-terminal His-tag.
Type: Recombinant Proteins
Assay Protocol: https://www.medchemexpress.com/cytokines/animal-free-light-tnfsf14-protein-human-his.html
Purity: 95.00
Smiles: MRLGEMVTRL PDGPAGSWEQ LIQERRSHEV NPAAHLTGAN SSLTGSGGPL LWETQLGLAF LRGLSYHDGA LVVTKAGYYY IYSKVQLGGV GCPLGLASTI THGLYKRTPR YPEELELLVS QQSPCGRATS SSRVWWDSSF LGGVVHLEAG EKVVVRVLDE RLVRLRDGTR SYFGAFMV
Molecular Weight: Approximately 20.30 kDa
References & Citations: [1]Mauri DN, et al. LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. Immunity. 1998 Jan;8(1):21-30.|[2]Han M, et al. Comprehensive characterization of TNFSF14/LIGHT with implications in prognosis and immunotherapy of human gliomas. Front Immunol. 2022 Oct 20;13:1025286.|[3]Manresa MC, et al. LIGHT controls distinct homeostatic and inflammatory gene expression profiles in esophageal fibroblasts via differential HVEM and LTβR-mediated mechanisms. Mucosal Immunol. 2022 Feb;15(2):327-337.|[4]Hou Y, et al. Dual Roles of Tumor Necrosis Factor Superfamily 14 in Antiviral Immunity. Viral Immunol. 2022 Nov;35(9):579-585.|[5]Miao X, et al. HES5-mediated repression of LIGHT transcription may contribute to apoptosis in hepatocytes. Cell Death Discov. 2021 Oct 23;7(1):308.|[6]Zhang H, et al. TNFSF14, a novel target of miR-326, facilitates airway remodeling in airway smooth muscle cells via inducing extracellular matrix protein deposition and proliferation. Kaohsiung J Med Sci. 2020 Jul;36(7):508-514.|[7]Holmes TD, et al. Licensed human natural killer cells aid dendritic cell maturation via TNFSF14/LIGHT. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):E5688-96.
Shipping Conditions: Blue Ice
Storage Conditions: Stored at -20°C for 2 years

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Cat	Name
HY-P700136AF-01	Animal-Free LIGHT/TNFSF14, Human (His)
HY-P700136AF-02	Animal-Free LIGHT/TNFSF14, Human (His)
HY-P700136AF-03	Animal-Free LIGHT/TNFSF14, Human (His)
HY-P700221AF-03	Animal-Free LIGHT/TNFSF14, Mouse (His)
HY-P700221AF-01	Animal-Free LIGHT/TNFSF14, Mouse (His)
HY-P700221AF-02	Animal-Free LIGHT/TNFSF14, Mouse (His)
HY-P72522-01	LIGHT/TNFSF14, Human (HEK293, His)
HY-P73281-01	LIGHT/TNFSF14, Human (HEK293, Fc)
HY-P73281-02	LIGHT/TNFSF14, Human (HEK293, Fc)
HY-P72522-02	LIGHT/TNFSF14, Human (HEK293, His)