Animal-Free LIGHT/TNFSF14, Mouse (His)

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Dry Ice Shipment: No

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CAT:

804-HY-P700221AF-02

Size:

2 µg

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Animal-Free LIGHT/TNFSF14, Mouse (His)

UNSPSC Description: LIGHT/TNFSF14 protein (CD258; TNFRSF14) is a type II transmembrane protein produced by activated T cells. It is a TNFRSF14/HVEM ligand and belongs to the tumor necrosis factor (TNF) family. LIGHT/TNFSF14 is mainly expressed in spleen, with two subtypes: membrane-bound type and soluble type [1]. LIGHT/TNFSF14 protein can be used as immune checkpoint molecule of tumor, and stimulate natural killer cells to produce interferon TFNγ, triggering tumor apoptosis signal [2]. LIGHT/TNFSF14 is also involved in the dominant LTβR-NIK-p52 NF-κB pathway promoting the expression of inflammatory gene[3]. In addition, LIGHT/TNFSF14 protein is a co-stimulatory factor that activates lymphoid cells and has an inhibitory effect on herpes virus infection[4]. Mouse LIGHT/TNFSF14 Protein has 239 amino acids and a transmembrane domain (38-58 a.a.). Animal-Free LIGHT/TNFSF14 Protein, Mouse (His) is the extracellular part (R58-V239) of mouse LIGHT/TNFSF14 Protein, produced by E.coli, with C-terminal His-tag.
Type: Recombinant Proteins
Assay Protocol: https://www.medchemexpress.com/cytokines/animal-free-light-tnfsf14-protein-mouse-his.html
Purity: 95.0
Smiles: MRLHQRLGDI VAHLPDGGKG SWEKLIQDQR SHQANPAAHL TGANASLIGI GGPLLWETRL GLAFLRGLTY HDGALVTMEP GYYYVYSKVQ LSGVGCPQGL ANGLPITHGL YKRTSRYPKE LELLVSRRSP CGRANSSRVW WDSSFLGGVV HLEAGEEVVV RVPGNRLVRP RDGTRSYFGA FMV
Molecular Weight: Approximately 20.92 kDa
References & Citations: [1]Mauri DN, et al. LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. Immunity. 1998 Jan;8(1):21-30.|[2]Han M, et al. Comprehensive characterization of TNFSF14/LIGHT with implications in prognosis and immunotherapy of human gliomas. Front Immunol. 2022 Oct 20;13:1025286.|[3]Manresa MC, et al. LIGHT controls distinct homeostatic and inflammatory gene expression profiles in esophageal fibroblasts via differential HVEM and LTβR-mediated mechanisms. Mucosal Immunol. 2022 Feb;15(2):327-337.|[4]Hou Y, et al. Dual Roles of Tumor Necrosis Factor Superfamily 14 in Antiviral Immunity. Viral Immunol. 2022 Nov;35(9):579-585.|[5]Miao X, et al. HES5-mediated repression of LIGHT transcription may contribute to apoptosis in hepatocytes. Cell Death Discov. 2021 Oct 23;7(1):308.|[6]Agostino M, et al. TNFSF14-Derived Molecules as a Novel Treatment for Obesity and Type 2 Diabetes. Int J Mol Sci. 2021 Sep 30;22(19):10647.|[7]Saunders BM, et al. Shining LIGHT on the metabolic role of the cytokine TNFSF14 and the implications on hepatic IL-6 production. Immunol Cell Biol. 2018 Jan;96(1):41-53.|[8]Krause P, et al. The tumor necrosis factor family member TNFSF14 (LIGHT) is required for resolution of intestinal inflammation in mice. Gastroenterology. 2014 Jun;146(7):1752-62.e4.
Shipping Conditions: Blue Ice
Storage Conditions: Stored at -20°C for 2 years

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Cat	Name
HY-P700221AF-01	Animal-Free LIGHT/TNFSF14, Mouse (His)
HY-P700221AF-02	Animal-Free LIGHT/TNFSF14, Mouse (His)
HY-P700221AF-03	Animal-Free LIGHT/TNFSF14, Mouse (His)
HY-P700136AF-01	Animal-Free LIGHT/TNFSF14, Human (His)
HY-P700136AF-02	Animal-Free LIGHT/TNFSF14, Human (His)
HY-P700136AF-03	Animal-Free LIGHT/TNFSF14, Human (His)
HY-P73837-01	LIGHT/TNFSF14, Mouse (sf9, His)
HY-P73837-02	LIGHT/TNFSF14, Mouse (sf9, His)
HY-P73837A-02	LIGHT/TNFSF14, Mouse (sf9, His, solution)
HY-P73837A-04	LIGHT/TNFSF14, Mouse (sf9, His, solution)