LD78-beta/CCL3L1

• Description:

  LD78-beta is a CC chemokine that is closely related to MIP-1 alpha. It signals through the CCR5 receptor and the beta-chemokine receptor, D6. LD78-beta has been shown to exhibit potent activity in HIV suppression assays. Recombinant human LD78-beta is a 7.7 kDa protein containing 70 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

• Synonyms:

  CCL3L1

• NCBI Gene ID:

  6349

• UniProt:

  P16619

• Accession Number:

  NP_066286.1

• Accession Number mRNA:

  NM_021006.4

• Chromosomal Location:

  17q21.1

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  APLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPSV IFLTKRGRQV CADPSEEWVQ KYVSDLELSA

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract mouse BaF3 cells expressing the CCR5 receptor using a concentration range of 5-25 ng/ml.

• Length:

  70

• Form:

  Lyophilized

• Molecular Weight:

  7.7 kDa

• Host or Source:

  E. coli