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IFN beta

CAT: 0209-100-191-L100Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-100-191-L100Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Proteins of this family play an important role in inducing non-specific resistance against a broad range of viral infections. They also affect cell proliferation and modulate immune responses. Produced by peripheral blood leukocytes and lymphoblastoid cells, IFN-alpha is an acid stable molecule that signals through IFN-alpha/betaR, which is also used by IFN-beta. Both IFNs have similar anti-viral activity and regulate expression of MHC class I antigens. IFN-alpha contains four highly conserved cysteine residues which form two disulfide bonds, one of which is necessary for biological activity. Recombinant human IFN-beta is a 20.0 kDa protein containing 166 amino acid residues. Due to glycosylation, IFN-beta has an approximate MW of 22.3 kDa based on SDS-PAGE gel and Mass Spectrometry.
Synonyms
IFNB1; IFB; IFF; IFNB
NCBI Gene ID
3456
UniProt
P01574
Accession Number
NP_002167.1
Accession Number mRNA
NM_002176
Chromosomal Location
9p21
Reactivity
Human
Cross Reactivity
Monkey, Mouse, Human
Sequence
MSYNLLGFLQ RSSNFQCQKL LWQLNGRLEY CLKDRMNFDI PEEIKQLQQF QKEDAALTIY EMLQNIFAIF RQDSSSTGWN ETIVENLLAN VYHQINHLKT VLEEKLEKED FTRGKLMSSL HLKRYYGRIL HYLKAKEYSH CAWTIVRVEI LRNFYFINRL TGYLRN
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
Assay #1: Determined by its ability to induce STAT1/STAT2 activation in human COLO 205 ISRE LUC reporter cells. Assay #2: Determined by a cytotoxicity assay using human TF-1 cells. The expected ED50 is ≤ 0.1 ng/ml (specific activity of ≥ 1 x 10^7 units/mg) .
Length
166
Form
Lyophilized
Molecular Weight
20 kDa
Host or Source
CHO cells

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