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GMF-beta

CAT: 0209-101-M436Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M436Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The high affinity receptor for granulocyte-macrophage colony stimulating factor (GM-CSF) consists of two subunits; an 80 kDa cytokine-specific alpha-subunit (CD116), and a 120 kDa non-specific, signal transducing beta-subunit (CD131) . Analogous with other cytokine signaling mechanisms, CD131 is also shared with the cytokine specific alpha-subunits of the IL-3 and IL-5 receptors. In the absence of CD131, the CD116 alpha-subunit binds GM-CSF with low affinity. GM-CSF receptors are highly expressed on neutrophils, monocytes, oligodendrocytes, megakaryocytes, eosinophils, and myeloid leukemia cells.
Synonyms
GMFB; GMF
NCBI Gene ID
2764
UniProt
P60983
Accession Number
NP_004115.1
Accession Number mRNA
NM_004124
Chromosomal Location
14q22.2
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human GMF-beta
Clone
(#8X12)
Applications
WB
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

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