I-TAC (CXCL11)

• Description:

  I-TAC is a "non-ELR" CXC chemokine that is regulated by interferon and signals through the CXCR3 receptor. I-TAC is chemoattractant for IL-2 activated T cells, but does not affect freshly isolated un-stimulated T cells, neutrophils, or monocytes. Recombinant murine I-TAC is a 9.0 kDa protein containing 79 amino acid residues including the four highly conserved cysteine residues present in CXC chemokines.

• Synonyms:

  CXCL11

• NCBI Gene ID:

  56066

• UniProt:

  Q9JHH5

• Accession Number:

  NP_062367.1

• Accession Number mRNA:

  NM_019494.1

• Chromosomal Location:

  5; 5 E3

• Reactivity:

  Mouse

• Cross Reactivity:

  Human, Mouse, Monkey, Bacteria

• Sequence:

  FLMFKQGRCLCIGPGMKAVKMAEIEKASVIYPSNGCDKVEVIVTMKAHKRQRCLDPRSKQARLIMQAIEKKNFLRRQNM

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract murine CXCR3 transfected HEK/293 cells using a concentration range of 10.0-100.0 ng/ml.

• Length:

  79

• Form:

  Lyophilized

• Molecular Weight:

  9.0 kDa

• Host or Source:

  E. coli