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Integrin alpha V (CD51)

CAT: 0209-101-M521Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M521Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM) . Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.
Synonyms
ITGAV; CD51; MSK8; VNRA
NCBI Gene ID
3685
UniProt
P06756
Accession Number
NP_002201.1
Accession Number mRNA
NM_002210.4
Chromosomal Location
2q31-q32
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human Integrin alphaV
Clone
(#3H31)
Applications
IHC (F), FC
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

UniProtKB · P06756

Integrin alpha-V

ITAV_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P06756
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ITGAV
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A0AV67, B0LPF4, B7Z883, B7ZLX0, D3DPG8, E7EWZ6, Q53SK4, Q59EB7, Q6LD15
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-binding

Biological process

Cell adhesionHost-virus interaction

Cellular component

Cell junctionCell membraneMembrane

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoprotein

Disease

Disease variant

Molecular function

Host cell receptor for virus entryIntegrinReceptor

Domain

RepeatSignalTransmembraneTransmembrane helix

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