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Integrin alpha 2 (CD49b)

CAT: 0209-101-M515Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M515Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM) . Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.
Synonyms
ITGA2; BR; GPIa; CD49B; VLA-2; VLAA2; BDPLT9
NCBI Gene ID
3673
UniProt
P17301
Accession Number
NP_002194.2
Accession Number mRNA
NM_002203.3
Chromosomal Location
5q11.2
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human Integrin alpha2
Clone
(#2B13)
Applications
IHC (F), FC
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

UniProtKB · P17301

Integrin alpha-2

ITA2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P17301
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ITGA2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q14595
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Ligand

CalciumMagnesiumMetal-binding

Biological process

Cell adhesionHost-virus interaction

PTM

Disulfide bondGlycoprotein

Molecular function

Host cell receptor for virus entryIntegrinReceptor

Cellular component

Membrane

Domain

RepeatSignalTransmembraneTransmembrane helix

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NBP3-03851-100ulRabbit Polyclonal Integrin alpha 2/CD49b Antibody
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MBS696944-01Anti-Mouse CD49b (Integrin alpha 2) FITC
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