IL-3 receptor alpha

• Description:

  Interleukin 3 (IL-3) is a pleiotropic cytokine that can stimulate proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. IL-3 exerts its activity through binding to a specific cell surface receptor known as IL-3 R. IL-3 R is a heterodimeric structure composed of a 70 kDa IL-3 R alpha subunit (CD123 or beta common) and a 120-140 kDa IL-3 R beta subunit (CD131) . CD131 also associates with the receptor for Erythropoietin, forming a tissue-protective hetero-receptor complex.

• Synonyms:

  Il3ra; CD123; SUT-1; CDw123

• NCBI Gene ID:

  16188

• UniProt:

  P26952

• Accession Number:

  NP_032395.1

• Accession Number mRNA:

  NM_008369.1

• Chromosomal Location:

  14 A2; 14 1.5 cM

• Reactivity:

  Anti-Mouse

• Cross Reactivity:

  Mouse

• Target Antigen:

  Recombinant protein of the EC domain of IL-3 R alpha

• Clone:

  (#9G52)

• Applications:

  WB

• Purification Method:

  Protein A/G chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source:

  Rat

• Isotype:

  IgG2