IL-1 R1

• Description :

  IL-1 receptor type I (IL1R-I) is an 80 kD transmembrane glycoprotein and a member of the immunoglobulin superfamily expressed on T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells and neural cells. IL1R-I binds the mature forms of IL-1α, IL-1β, and IL-1Ra proteins. High affinity binding and signaling by the type I IL-1 receptor requires CD121a and the accessory protein, IL-1R AcP, which does not bind IL-1 alone, but forms a dimer capable of binding IL-1.

• Synonyms :

  Il1r1; IL-iR; CD121a; CD121b; Il1r-1; Interleukin 1 receptor 1

• NCBI Gene ID :

  16177

• UniProt :

  P13504

• Accession Number :

  NP_032388.1

• Accession Number mRNA :

  NM_008362.2

• Chromosomal Location :

  1 B; 1 19.5 Cm

• Reactivity :

  Anti-Mouse

• Cross Reactivity :

  Mouse

• Target Antigen :

  Extracellular domain of mouse IL1R-I

• Clone :

  (#11B7)

• Applications :

  WB

• Purification Method :

  Protein G/A chromatography

• Assay Protocol :

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form :

  Lyophilized

• Buffer :

  PBS

• Reconstitution :

  PBS

• Storage Conditions :

  Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source :

  Rat

• Isotype :

  IgG2