IL-1 R1

• Description:

  IL-1 receptor type I (IL1R-I) is an 80 kD transmembrane glycoprotein and a member of the immunoglobulin superfamily expressed on T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells and neural cells. IL1R-I binds the mature forms of IL-1α, IL-1β, and IL-1Ra proteins. High affinity binding and signaling by the type I IL-1 receptor requires CD121a and the accessory protein, IL-1R AcP, which does not bind IL-1 alone, but forms a dimer capable of binding IL-1.

• Synonyms:

  Il1r1; IL-iR; CD121a; CD121b; Il1r-1; Interleukin 1 receptor 1

• NCBI Gene ID:

  16177

• UniProt:

  P13504

• Accession Number:

  NP_032388.1

• Accession Number mRNA:

  NM_008362.2

• Chromosomal Location:

  1 B; 1 19.5 Cm

• Reactivity:

  Anti-Mouse

• Cross Reactivity:

  Mouse

• Target Antigen:

  Extracellular domain of mouse IL1R-I

• Clone:

  (#11B7)

• Applications:

  WB

• Purification Method:

  Protein G/A chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source:

  Rat

• Isotype:

  IgG2