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IL-1 alpha

CAT: 0209-102-P30Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-102-P30Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IL1α and IL1β are both synthesized as 31 kDa precursors that are subsequently cleaved into proteins with molecular weights of approximately 17,000 Da. Neither precursor contains a typical hydrophobic signal peptide sequence and most of the precursor form of IL1α remains in the cytosol of cells, although there is evidence for a membranebound form of the precursor form of IL1α. The IL1α precursor reportedly shows full biological activity in the EL4 assay. Among various species, the amino acid sequence of mature IL 1α is conserved 60% to 70% and human IL1 has been found to be biologically active on murine cell lines. Both forms of IL1 bind to the same receptors, designated type I and type II. Evidence suggests that only the type I receptor is capable of signal transduction and that the type II receptor may function as a decoy, binding IL1 and thus preventing binding of IL1 to the type I receptor.
Synonyms
IL1A; IL1; IL-1A; IL1F1; IL1-ALPHA
NCBI Gene ID
3552
UniProt
P01583
Accession Number
NP_000566.3
Accession Number mRNA
NM_000575
Chromosomal Location
2q14
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human IL-1 alpha
Clone
Rabbit IgG
Applications
ELISA, WB, N
Purification Method
Antigen-affinity purified
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Form
Lyophilized from PBS
Buffer
PBS
Reconstitution
Water
Storage Conditions
The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
Host or Source
Rabbit

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