RegisterLogin

IL-1 beta

CAT: 0209-M10-013-L250Size: 250 µgDry Ice: NoHazardous: No
CAT#:0209-M10-013-L250Size:250 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
IL-1β is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant murine IL-1β is a 17.5 kDa protein containing 153 amino acid residues.
Synonyms
Il1b; Il-1b; IL-1beta
NCBI Gene ID
16176
UniProt
P10749
Accession Number
NP_032387
Accession Number mRNA
NM_008361
Chromosomal Location
2 F; 2 73.0 cM
Reactivity
Mouse
Cross Reactivity
Human, Monkey, Pig, Rat, Mouse
Sequence
MVPIRQLHYR LRDEQQKSLV LSDPYELKAL HLNGQNINQQ VIFSMSFVQG EPSNDKIPVA LGLKGKNLYL SCVMKDGTPT LQLESVDPKQ YPKKKMEKRF VFNKIEVKSK VEFESAEFPN WYISTSQAEH KPVFLGNNSG QDIIDFTMES VSS
Assay Protocol
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 as determined by the dose-dependent stimulation of murine D10S cells is ≤ 0.002 ng/ml, corresponding to a specific activity of ≥ 5 x 108 units/mg.
Length
153
Form
Lyophilized
Buffer
10mM Sodium Citrate, pH 4.0
Reconstitution
Water
Molecular Weight
17.5 kDa
Storage Conditions
The lyophilized protein is stable at room temperature for 1 month and at 4°C for 6 months. Reconstituted working aliquots are stable for 1 week at 2°C to 8°C and for 6 months at -20°C to -80°C.
Host or Source
E. coli

Related Products

CatalogName
100-091SIL-36 beta (IL-1F8)
100-091-L500IL-36 beta (IL-1F8)
100-091-L1000IL-36 beta (IL-1F8)
100-091-L100IL-36 beta (IL-1F8)
100-091-L250IL-36 beta (IL-1F8)
100-091IL-36 beta (IL-1F8)
101-M476IL-12 receptor beta 1 EC
R20-006-L250IL-3 beta
R20-006-L1000IL-3 beta
R20-006-L500IL-3 beta

Alternative Products

CatalogName
216650Interleukin 1 beta (IL-1b, IL-1 beta)
366963Interleukin-1 beta (Interleukin1 beta, IL-1 beta, IL-1b, IL-1beta)
GWB-A19523IL-1 BETA
369380-01Interleukin-1 Beta (IL-1b, Catabolin, IL-1, IL-1B, IL1-BETA, IL-1 Beta, IL1F2)
168271IL-1B (IL-1 beta, Interleukin-1 beta, IL-1ß, catabolin) (Biotin)
168266IL-1B (IL-1 beta, Interleukin-1 beta, IL-1b, catabolin)
144768Interleukin-1 beta (IL-1 beta)
I7663-09SInterleukin 1 beta (IL-1b, Catabolin, IL-1, IL-1B, IL1-BETA, IL-1 beta, IL1F2) (Carboxyfluorescein) discontinued
I7663-09QInterleukin 1 beta (IL-1b, Catabolin, IL-1, IL-1B, IL1-BETA, IL-1 beta, IL1F2) (PerCP) discontinued
I7663-09PInterleukin 1 beta (IL-1b, Catabolin, IL-1, IL-1B, IL1-BETA, IL-1 beta, IL1F2) (PE) discontinued

Popular Products