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Interferon gamma (IFN) R1

CAT: 0209-101-M799Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M799Size:100 µg
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Description
The high-affinity IFN-gamma receptor complex is made up of two type I membrane proteins, IFN-gamma R1 (IFN-gamma R alpha) and IFN-gamma R2 (IFN-gamma R beta) . Both proteins are members of the type II cytokine receptor family and share approximately 52% amino acid sequence identity. IFN-gamma R1 is the ligand-binding subunit that is necessary and sufficient for IFN-gamma binding and receptor internalization. IFN-gamma R2 is required for IFN-gamma signalling but does not bind IFN-gamma by itself. Human IFN-gamma R1 cDNA encodes a 499 amino acid (aa) residue protein with a 17 aa signal peptide, a 228 aa extracellular domain, a 23 aa transmembrane domain, and a 221 aa intracellular domain. Human and mouse IFN-gamma R1 share 52% amino acid sequence identity and bind IFN-gamma in a species-specific manner. IFN-gamma R1 is constitutively expressed in most cell types. Soluble IFN-gamma R1 that binds IFN-gamma has been detected in biological fluids.
Synonyms
Interferon gamma receptor 1, IFN-gamma receptor 1; IFN-gamma-R1, CDw119, Interferon gamma receptor alpha-chain (IFN-gamma-R-alpha), CD119
NCBI Gene ID
3459
UniProt
P15260
Accession Number
NP_000407.1
Accession Number mRNA
NM_000416.2
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Human recombinant IFN gamma RI EC domain
Clone
(#7K51)
Applications
WB, FC, N
Purification Method
Protein G chromatography
Assay Protocol
Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

UniProtKB · P15260

Interferon gamma receptor 1

INGR1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P15260
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IFNGR1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IFN-gamma receptor 1, IFN-gamma-R1
EC number
—
Processing
Precursor
Secondary accessions
B4DFT7, E1P587, Q53Y96
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembrane

Disease

Disease variant

PTM

Disulfide bondGlycoproteinPhosphoproteinUbl conjugation

Domain

Immunoglobulin domainSignalTransmembraneTransmembrane helix

Molecular function

Receptor

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