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IL-1 alpha

CAT: 0209-R20-024Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0209-R20-024Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IL-1α is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant rat IL-1α is a 17.7 kDa protein containing 155 amino
Synonyms
Il1a; IL-1 alpha
NCBI Gene ID
24493
UniProt
P16598
Accession Number
NP_058715.1
Accession Number mRNA
NM_017019
Chromosomal Location
3q36
Reactivity
Rat
Cross Reactivity
Mouse, Rat
Sequence
MAPHSFQNNL RYKLIRIVKQ EFIMNDSLNQ NIYVDMDRIH LKAASLNDLQ LEVKFDMYAY SSGGDSKYPV TLKVSNTQLF VSAQGEDKPV LLKEIPETPK LITGSETDLI FFWEKINSKN YFTSAAFPEL LIATKEQSQV HLARGLPSMI DFQIS
Assay Protocol
Reconstitute in0.5X PBS to a concentration of 0.1-1.0mg/mL.
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 as determined by the dose-dependent proliferation of murine D10S cells is < 0.005 ng/ml, corresponding to a specific activity of > 2 x 108 units/mg.
Length
155
Form
Lyophilized
Buffer
PBS
Reconstitution
0.5X PBS
Molecular Weight
17.7 kDa
Host or Source
E. coli

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