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IL-1 alpha

CAT: 0209-M10-012SSize: 2 µgDry Ice: NoHazardous: No
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CAT#:0209-M10-012SSize:2 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IL-1α is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant murine IL-1α is an 17.9 kDa protein containing 156 amino acid residues.
Synonyms
Il1a; Il-1a
NCBI Gene ID
16175
UniProt
P01582
Accession Number
NP_034684.2
Accession Number mRNA
NM_010554
Chromosomal Location
2F;273.0cM
Reactivity
Mouse
Cross Reactivity
Mouse, Human, Rat
Sequence
SAPYTYQSDL RYKLMKLVRQ KFVMNDSLNQ TIYQDVDKHY LSTTWLNDLQ QEVKFDMYAY SSGGDDSKYP VTLKISDSQL FVSAQGEDQP VLLKELPETP KLITGSETDL IFFWKSINSK NYFTSAAYPE LFIATKEQSR VHLARGLPSM TDFQIS
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 as determined by the dose-dependent stimulation of murine D10S cells is < 0.002 ng/ml, corresponding to a specific activity of > 5 x 108 units/mg.
Length
159
Form
Lyophilized
Molecular Weight
17.9 kDa
Host or Source
E. coli

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