IFN lambda2 (IL-28A) Recombinant Protein

IFN lambda2 (IL-28A) Recombinant Protein

• Description: IFN lambda-1,-2, and -3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and Interferons. All three IFN-lambdas uses a distinct receptor system composed of an IFN-lambdaR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14). Signaling through this receptor system induces antiviral defense similar but distinct than the type I Interferons. Recombinant murine IFN-lambda2 is a 19.8 kDa protein containing 175 amino acid residues.
• Synonyms: IL28A; IFNL2; IL-28A
• CAS Number: 9000-83-3
• NCBI Gene ID: 282616
• UniProt: Q8IZJ0
• Accession Number: NP_742150.1
• Accession Number mRNA: NM_172138
• Gene Location: 19q13.13
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Human
• Sequence: PVARLHGALP DARGCHIAQF KSLSPQELQA FKRA KDALEE SLLLKDCRCH SRLFPRTWDL RQLQVRERPM ALEAELALTL KVLEATADTD PALVDVLDQP LHTLHHILSQ FRACIQPQPT AGPRTRGRLH HWLYRLQEAP KKESPGCLEA SVTFNLFRLL TRDLNCVASG DLCV
• Detection Range: Determined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO205 cells. The expected ED50 is 0.3-0.5 ng/ml.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Length: 174
• Form: Lyophilized
• Molecular Weight: 19.6 kDa
• Shipping Conditions: Room Temperature