IFN lambda2 (IL-28A)

• Description:

  IFN lambda-1, -2, and -3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and Interferons. All three IFN-lambdas uses a distinct receptor system composed of an IFN-lambdaR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14) . Signaling through this receptor system induces antiviral defense similar but distinct than the type I Interferons. Recombinant murine IFN-lambda2 is a 19.8 kDa protein containing 175 amino acid residues.

• Synonyms:

  IL28A; IFNL2; IL-28A

• NCBI Gene ID:

  282616

• UniProt:

  Q8IZJ0

• Accession Number:

  NP_742150.1

• Accession Number mRNA:

  NM_172138

• Chromosomal Location:

  19q13.13

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  PVARLHGALP DARGCHIAQF KSLSPQELQA FKRA KDALEE SLLLKDCRCH SRLFPRTWDL RQLQVRERPM ALEAELALTL KVLEATADTD PALVDVLDQP LHTLHHILSQ FRACIQPQPT AGPRTRGRLH HWLYRLQEAP KKESPGCLEA SVTFNLFRLL TRDLNCVASG DLCV

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO205 cells. The expected ED50 is 0.3-0.5 ng/ml.

• Length:

  174

• Form:

  Lyophilized

• Molecular Weight:

  19.6 kDa

• Host or Source:

  E. coli