IL-36 beta (IL-1F8) Recombinant Protein

IL-36 beta (IL-1F8) Recombinant Protein

• Description: The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36α (IL-1F6), β (IL-1F8) and γ (IL-1F9). IL-36β is highly expressed in psoriatic plaques, and at lower levels in various other tissues. IL-36β signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36β also functions as an agonist of NF-kappaB, and stimulates the production of pro-inflammatory proteins, including IL-6, IL-8, BD-2, and BD-3. Recombinant human IL-36β is a 17.3 kDa protein containing 154 amino acid residues.
• Synonyms: FIL1; FIL1H; IL1F8; IL1H2; IL-1F8; IL-1H2; IL1-ETA; FIL1-(ETA); FILI-(ETA)
• CAS Number: 9000-83-3
• NCBI Gene ID: 27177
• UniProt: Q9NZH7
• Accession Number: NP_055253.2
• Accession Number mRNA: NM_014438
• Gene Location: 2q14
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Human
• Sequence: MREAAPKSYA IRDSRQMVWV LSGNSLIAAP LSRSIKPVTL HLIACRDTEF SDKEKGNMVY LGIKGKDLCL FCAEIQGKPT LQLKEKNIMD LYVEKKAQKP FLFFHNKEGS TSVFQSVSYP GWFIATSTTS GQPIFLTKER GITNNTNFYL DSVE
• Detection Range: Measured by its ability to induce IL-8 production by human PBMCs.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Length: 154
• Form: Lyophilized
• Molecular Weight: 17.3 kDa
• Shipping Conditions: Room Temperature