IFN lambda1 (IL-29) Recombinant Protein

IFN lambda1 (IL-29) Recombinant Protein

• Description: IFN lambda-1,-2, and -3 are distantly related to the IL-10 family and interferons. All three IFN-lambdas use a distinct receptor system composed of an IFN-lambdaR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14). Signaling through this receptor system induces antiviral defense similar but distinct than the type I interferons (Kotenko, SV. et al. Nat Immunology 2003 [1] p. 69-77). Recombinant human IFN-lambda 1 is a 19.8 kDa protein containing 178 amino acid residues.
• Synonyms: IL29; IFNL1; IL-29; IL-29, IL-28A; IL-28B
• CAS Number: 9000-83-3
• NCBI Gene ID: 282618
• UniProt: Q8IU54
• Accession Number: NP_742152.1
• Accession Number mRNA: NM_172140.1
• Gene Location: 19q13.13
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Human, Monkey
• Sequence: PTSKPTTTGK GCHIGRFKSL SPQELASFKK ARDALEESLK LKNWSCSSPV FPGNWDLRLL QVRERPVALE AELALTLKVL EAAAGPALED VLDQPLHTLH HILSQLQACI QPQPTAGPRP RGRLHHWLHR LQEAPKKESA GCLEASVTFN LFRLLTRDLK YVADGNLCLR TSTHPEST
• Detection Range: Determined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO205 cells. The expected ED50 is 0.2-0.5 ng/ml.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Length: 178
• Form: Lyophilized
• Molecular Weight: 19.8 kDa
• Shipping Conditions: Room Temperature