IL-36 gamma (IL-1F9) Recombinant Protein

IL-36 gamma (IL-1F9) Recombinant Protein

• Description: The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36 α (IL-1F6), β (IL-1F8) and γ (IL-1F9). IL-36γ is highly expressed in psoriatic plaques and in tissues containing epithelial cells. IL-36γ signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36γ also functions as an agonist of NF-kappaB, and can stimulate the inflammatory response in bronchial epithelial cells. Recombinant human IL-36γ is a 17.0 kDa protein containing 152 amino acid residues.
• Synonyms: IL1E; IL1F9; IL1H1; IL-1F9; IL-1H1; IL1RP2; IL-1RP2
• CAS Number: 9000-83-3
• NCBI Gene ID: 56300
• UniProt: Q9NZH8
• Accession Number: NP_062564.1
• Accession Number mRNA: NM_019618.3
• Gene Location: 2q12-q21
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Human
• Sequence: SMCKPITGTI NDLNQQVWTL QGQNLVAVPR SDSVTPVTVA VITCKYPEAL EQGRGDPIYL GIQNPEMCLY CEKVGEQPTL QLKEQKIMDL YGQPEPVKPF LFYRAKTGRT STLESVAFPD WFIASSKRDQ PIILTSELGK SYNTAFELNI ND
• Detection Range: Measured by its ability to induce IL-8 production by human PBMCs.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 95% by SDS-PAGE & HPLC analyses
• Length: 152
• Form: Lyophilized
• Molecular Weight: 17 kDa
• Shipping Conditions: Room Temperature