GDNFR alpha 4

• Description:

  GFR alpha -1, -2, -3, and -4 are GPI-anchored receptors that interact preferentially with the GDNF family ligands GDNF, Neurturin, Artemin, and Persephin, respectively. GFR alpha proteins initiate signaling in association with the receptor tyrosine kinase RET and by RET-independent pathways. GFR alpha-mediated signaling is instrumental in the differentiation, migration, and support of central and peripheral neurons. Alternative splicing generates multiple isoforms of GFR alpha proteins.

• Synonyms:

  Gfra4; AW060733; G630015H18Rik

• NCBI Gene ID:

  14588

• UniProt:

  Q9JJT2

• Accession Number:

  NP_064398.1

• Accession Number mRNA:

  NM_020014

• Chromosomal Location:

  2 F1; 2 73.9 cM

• Reactivity:

  Anti-Mouse

• Cross Reactivity:

  Mouse

• Target Antigen:

  Recombinant mouse protein GFR alpha 4

• Clone:

  (#1M21)

• Applications:

  ELISA, IHC (F)

• Purification Method:

  Protein G/A chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source:

  Rat

• Isotype:

  IgG2