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GDNFR alpha 2

CAT: 0209-101-M438Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M438Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GDNF family receptor alpha-1 is a protein that in humans is encoded by the GFRA1 gene. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI) -linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Synonyms
Glial cell line derived neurotrophic factor receptor alpha 2
NCBI Gene ID
2675
UniProt
O00451
Accession Number
NP_001158510.1
Accession Number mRNA
NM_001165038.1
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human GDNF-Ralpha2
Clone
(#11G34)
Applications
WB
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

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