Mouse Anti-Human GDNF-R alpha 2 (GFR alpha 2) Monoclonal Antibody

• Description:

  GDNF family receptor alpha-1 is a protein that in humans is encoded by the GFRA1 gene. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

• Synonyms:

  glial cell line derived neurotrophic factor receptor alpha 2

• NCBI Gene ID:

  2675

• UniProt:

  O00451

• Accession Number:

  NP_001158510.1

• Accession Number mRNA:

  NM_001165038.1

• Host:

  Mouse

• Origin Species:

  Human

• Species Reactivity:

  Human

• Target Antigen:

  Human Recombinant GDNF-R alpha 2 (GFR alpha 2)

• Isotype:

  IgG1

• Clone:

  (#6D46)

• Validated Applications:

  WB, FC

• Purification Method:

  Protein G chromatography

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.

• CAS Number:

  9007-83-4