FGF-18 (Animal Free)

• Description:

  FGF-18 is a heparin-binding growth factor that belongs to the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-18 is an essential regulator of long bone and calvarial development. FGF-18 signals through FGFR 1c, 2c, 3c, and 4. Recombinant Human FGF-18 derived from E.coli is a 20.1 kDa protein consisting of 173 amino acid residues, resulting from C-terminal truncation of the full length protein.

• Synonyms:

  FGF18; ZFGF5; FGF-18

• NCBI Gene ID:

  8817

• UniProt:

  O76093

• Accession Number:

  NP_003853.1

• Accession Number mRNA:

  NM_003862

• Chromosomal Location:

  5q34

• Reactivity:

  Human

• Cross Reactivity:

  Mouse, Rat, Human

• Sequence:

  AEENVDFRIH VENQTRARDD VSRKQLRLYQ LYSRTSGKHI QVLGRRISAR GEDGDKYAQL LVETDTFGSQ VRIKGKETEF YLCMNRKGKL VGKPDGTSKE CVFIEKVLEN NYTALMSAKY SGWYVGFTKK GRPRKGPKTR ENQQDVHFMK RYPKGQPELQ KPFKYTTVTK RSR

• Endotoxin:

  < 0.01 ng/µg of protein (< 0.1 EU/µg)

• Purity:

  ≥ 95% by SDS-PAGE gel and HPLC analyses.

• Bioactivity:

  Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 10 ng/ml, corresponding to a specific activity of ≥ 1 x 105 units/mg.

• Length:

  173

• Form:

  Lyophilized

• Molecular Weight:

  20.1 kDa

• Host or Source:

  E. coli