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FGF-21 (Animal Free)

CAT: 0209-100-337S-AFSize: 5 µgDry Ice: NoHazardous: No
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CAT#:0209-100-337S-AFSize:5 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FGF-21 is a secreted growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-21, in the presence of β-Klotho as a protein cofactor, signals through FGFR 1c and 4 receptors, and stimulates insulin-independent glucose uptake by adipocytes. Recombinant Human FGF-21 is a 19.5 kDa protein containing 182 amino acid residues.
Synonyms
FGF21
NCBI Gene ID
26291
UniProt
Q9NSA1
Accession Number
NP_061986.1
Accession Number mRNA
NM_019113
Chromosomal Location
19q13.1-qter
Reactivity
Human
Cross Reactivity
Mouse
Sequence
MHPIPDSSPL LQFGGQVRQR YLYTDDAQQT EAHLEIREDG TVGGAADQSP ESLLQLKALK PGVIQILGVK TSRFLCQRPD GALYGSLHFD PEACSFRELL LEDGYNVYQS EAHGLPLHLP GNKSPHRDPA PRGPARFLPL PGLPPALPEP PGILAPQPPD VGSSDPLSMV GPSQGRSPSY AS
Endotoxin
< 0.01 ng/µg of protein (< 0.1 EU/µg)
Purity
≥ 95% by SDS-PAGE gel and HPLC analyses.
Bioactivity
Determined by its ability to stimulate the proliferation of murine NIH-3T3 cells. The expected ED50 for this effect is 0.3-0.6 μg/ml, in the presence of murine Klotho.
Length
182
Form
Lyophilized
Molecular Weight
19.5 kDa
Host or Source
E. coli

UniProtKB · Q9NSA1

Fibroblast growth factor 21

FGF21_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9NSA1
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FGF21
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
FGF-21
EC number
—
Processing
Precursor
Secondary accessions
Q8N683
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Molecular function

Growth factor

Cellular component

Secreted

Domain

Signal

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