FGF-21 (Animal Free)

• Description:

  FGF-21 is a secreted growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-21, in the presence of β-Klotho as a protein cofactor, signals through FGFR 1c and 4 receptors, and stimulates insulin-independent glucose uptake by adipocytes. Recombinant Human FGF-21 is a 19.5 kDa protein containing 182 amino acid residues.

• Synonyms:

  FGF21

• NCBI Gene ID:

  26291

• UniProt:

  Q9NSA1

• Accession Number:

  NP_061986.1

• Accession Number mRNA:

  NM_019113

• Chromosomal Location:

  19q13.1-qter

• Reactivity:

  Human

• Cross Reactivity:

  Mouse

• Sequence:

  MHPIPDSSPL LQFGGQVRQR YLYTDDAQQT EAHLEIREDG TVGGAADQSP ESLLQLKALK PGVIQILGVK TSRFLCQRPD GALYGSLHFD PEACSFRELL LEDGYNVYQS EAHGLPLHLP GNKSPHRDPA PRGPARFLPL PGLPPALPEP PGILAPQPPD VGSSDPLSMV GPSQGRSPSY AS

• Endotoxin:

  < 0.01 ng/µg of protein (< 0.1 EU/µg)

• Purity:

  ≥ 95% by SDS-PAGE gel and HPLC analyses.

• Bioactivity:

  Determined by its ability to stimulate the proliferation of murine NIH-3T3 cells. The expected ED50 for this effect is 0.3-0.6 μg/ml, in the presence of murine Klotho.

• Length:

  182

• Form:

  Lyophilized

• Molecular Weight:

  19.5 kDa

• Host or Source:

  E. coli