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CTLA-4

CAT: 0209-103-M351Size: 50 µgDry Ice: NoHazardous: No
CAT#:0209-103-M351Size:50 µg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA-4 is up-regulated rapidly following T cell activation and CD28 ligation. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28.
Synonyms
Ctla4; Cd152; Ly-56; Ctla-4
NCBI Gene ID
12477
UniProt
P09793
Accession Number
NP_033973.2
Accession Number mRNA
NM_009843.3
Chromosomal Location
1 C; 1 30.1 cM
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Recombinant protein of CTLA-4
Clone
(#6G10)
Applications
WB, FC, N
Purification Method
Protein G/A chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Rat
Isotype
IgG2

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