Common beta chain (CD131)

CAT: 0209-101-M333Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-101-M333Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The high-affinity receptors for Interleukin-3 (IL-3), IL-5, and Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF) consist of a cytokine-specific a chain, and a shared common beta chain subunit (CD131) that is essential for receptor signaling. CD131 also associates with the receptor for Erythropoietin, forming a tissue-protective heteroreceptor complex. Phosphorylation of CD131 following receptor activation imparts growth and survival signals to the responding hematopoietic cells.
Synonyms
Common beta chain
NCBI Gene ID
1439
UniProt
P32927
Accession Number
NP_000386.1
Accession Number mRNA
NM_000395.2
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Human recombinant Common beta chain
Clone
(#7D20)
Applications
WB
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

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