CCL-3 (MIP1 alpha)

CAT: 0209-101-M187Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-101-M187Size:100 µg
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Description
The macrophage inflammatory proteins 1α and 1β were originally copurified from medium conditioned by an LPS-stimulated murine macrophage cell line. Human MIP1α refers to the products of several independently cloned cDNAs, including LD78, pL78, pAT464, and GOS19. These cDNAs all code for the same human protein that is a homologue of the murine MIP 1α. Mature MIP1α and MIP1β in both human and mouse share approximately 70% homology at the amino acid level. The MIP1 proteins are members of the β (CC) subfamily of chemokines. Both MIP1α and MIP1β are monocyte chemoattractants in vitro. Additionally, the MIP1 proteins have been reported to have chemoattractant and adhesive effects on lymphocytes, with MIP1α and MIP1β preferentially attracting CD8+ and CD4+ T cells, respectively. MIP1α has also been shown to attract B cells as well as eosinophils. MIP1 proteins have been reported to have multiple effects on hematopoietic precursor cells and MIP1α has been identified as a stem cell inhibitory factor that can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. The functional receptor for MIP1α has been identified as CCR1 and CCR5.
Synonyms
CCL3; MIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP-1-alpha
NCBI Gene ID
6348
UniProt
P10147
Accession Number
NP_002974
Accession Number mRNA
NM_002983
Chromosomal Location
17q12
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human CCL-3
Clone
(#7D34)
Applications
Detection Ab
Purification Method
Protein G chromatography
Assay Protocol
Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

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Alternative Products

CatalogName
138618CCL3, Recombinant, Mouse, aa24-92, His-Tag (C-C Motif Chemokine 3 , AI323804, G0S19-1, LD78alpha, MIP-1alpha, MIP1- (a), MIP1-alpha, Mip1a, Scya3)
352979MIP1 alpha, BioAssayTM ELISA Kit (Mouse) (Chemokine (C-C Motif) Ligand 3, Macrophage Inflammatory Protein-1 alpha, CCL3)
MBS650418-01Macrophage Inflammatory Protein 1 alpha, Recombinant, Mouse (Ccl3, Chemokine (C-C Motif) Ligand 3, AI323804, CCL3, G0S19-1, Heparin-binding Chemotaxis Protein, L2G25B, LD78alpha, Macrophage Inflammatory Protein 1-alpha, MIP1-(a), Mip1a, MIP1-alpha, MIP-1a
M1202-09DMacrophage Inflammatory Protein 1 alpha, Recombinant, Mouse (Ccl3, Chemokine (C-C Motif) Ligand 3, AI323804, CCL3, G0S19-1, Heparin-binding Chemotaxis Protein, L2G25B, LD78alpha, Macrophage Inflammatory Protein 1-alpha, MIP1- (a), Mip1a, MIP1-alpha, MIP-1alpha, MIP-1 alpha, MIP-1-alpha, Scya3, SIS-alpha, Small Inducible Cytokine A3 Precursor, TY-5)
364151MIP1a (Macrophage Inflammatory Protein 1 Alpha, CCL3, MIP1-A, SCYA3, Chemokine C-C-Motif Ligand 3, Small Inducible Cytokine A3, Homologous To Mouse Mip-1a, Tonsillar Lymphocyte LD78 Alpha Protein)
141345Macrophage Inflammatory Protein 1 Alpha (MIP1a, CCL3, MIP1-A, SCYA3, Chemokine C-C-Motif Ligand 3, Small Inducible Cytokine A3, Homologous To Mouse Mip-1a)
141346Macrophage Inflammatory Protein 1 Alpha (MIP1a, CCL3, MIP1-A, SCYA3, Chemokine C-C-Motif Ligand 3, Small Inducible Cytokine A3, Homologous To Mouse Mip-1a) discontinued
141346-HRPMacrophage Inflammatory Protein 1 Alpha (MIP1a, CCL3, MIP1-A, SCYA3, Chemokine C-C-Motif Ligand 3, Small Inducible Cytokine A3, Homologous To Mouse Mip-1a) (HRP) discontinued
141346-FITCMacrophage Inflammatory Protein 1 Alpha (MIP1a, CCL3, MIP1-A, SCYA3, Chemokine C-C-Motif Ligand 3, Small Inducible Cytokine A3, Homologous To Mouse Mip-1a) (FITC) discontinued
141346-BiotinMacrophage Inflammatory Protein 1 Alpha (MIP1a, CCL3, MIP1-A, SCYA3, Chemokine C-C-Motif Ligand 3, Small Inducible Cytokine A3, Homologous To Mouse Mip-1a) (Biotin) discontinued

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