BMP-4 Recombinant Protein

BMP-4 Recombinant Protein

• Description: Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Recombinant human BMP-4, expressed in HeLa cells, is a 31-36 kDa homodimeric glycoprotein.
• Synonyms: BMP4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS7
• CAS Number: 9000-83-3
• NCBI Gene ID: 652
• UniProt: P12644
• Accession Number: NP_001193
• Accession Number mRNA: NM_001202
• Gene Location: 14q22-q23
• Host: HeLa Cells
• Origin Species: Human
• Species Reactivity: Human, Mouse, Rat
• Sequence: HHSQRARKKN KNCRRHSLYV DFSDVGWNDW IVAPPGYQAF YCHGDCPFPL ADHLNSTNHA IVQTLVNSVN SSIPKACCVP TELSAISMLY LDEYDKVVLK NYQEMVVEGC GCR
• Detection Range: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 2-8 ng/ml.
• Purity: >97% by SDS-PAGE and HPLC anaylsis
• Length: 113
• Form: Lyophilized
• Molecular Weight: 25,6 kDa
• Shipping Conditions: Room Temperature