BMP-4 (E. coli , Animal Free) Recombinant Protein

BMP-4 (E. coli , Animal Free) Recombinant Protein

• Description: Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body, and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. PeproTech’s E.coli-derived BMP-4 is a fully active homodimeric protein consisting of two 106 amino acid subunits, which correspond to amino acids 303-408 of the full length BMP-4 precursor.  The calculated molecular weight of Recombinant Human BMP-4 (E.coli-derived) is 23.9 kDa.
• Synonyms: BMP4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS8
• CAS Number: 9000-83-3
• NCBI Gene ID: 652
• UniProt: P12644
• Accession Number: NP_001193
• Accession Number mRNA: NM_001202
• Gene Location: 14q22-q23
• Host: E. coli
• Origin Species: Human
• Sequence: KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAIVQTLVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR
• Detection Range: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 5-10 ng/ml.
• Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses
• Length: 106
• Form: Lyophilized
• Molecular Weight: 23,9 kDa
• Shipping Conditions: Room Temperature