BMP-4 Recombinant Protein

BMP-4 Recombinant Protein

• Description: Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Recombinant human BMP-4, expressed in HeLa cells, is a 31-36 kDa homodimeric glycoprotein.
• Synonyms: BMP4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6
• CAS Number: 9000-83-3
• NCBI Gene ID: 652
• UniProt: P12644
• Accession Number: NP_001193
• Accession Number mRNA: NM_001202
• Gene Location: 14q22-q23
• Host: CHO
• Origin Species: Human
• Species Reactivity: Human, Mouse, Rat
• Sequence: SPKHHSQRAR KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAI VQT LVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR.
• Detection Range: The ED50, as calculated by Alkaline phosphatase activity induced in ATDC-5 cells is 15ng/ml corresponding to a specific activity which is 6.7 x 10^4 units/mg.
• Purity: >95% by SDS-PAGE
• Length: 116
• Form: Lyophilized
• Buffer: 2XS PBS + 6% EtOH
• Molecular Weight: 26,2 kDa
• Shipping Conditions: Room Temperature