BD-4 Recombinant Protein

BD-4 Recombinant Protein

• Description: Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, four human β-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. The β-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. β-defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues. BD-4 is expressed in testis, stomach, uterus, neutrophils, thyroid, lung and kidney. In addition to its direct antimicrobial activities, BD-4 is chemo attractant towards human blood monocytes. Recombinant human BD-4 is a 6.0 kDa protein containing 50 amino acid residues.
• Synonyms: DEFB104A; BD-4; DEFB4; hBD-4; DEFB-4; DEFB104; DEFB104B
• CAS Number: 9000-83-3
• NCBI Gene ID: 140596
• UniProt: Q8WTQ1
• Accession Number: NP_525128.2
• Accession Number mRNA: NM_080389.2
• Gene Location: 8p23.1
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Human
• Sequence: EFELDRICGY GTARCRKKCR SQEYRIGRCP NTYACCLRKW DESLLNRTKP
• Detection Range: Determined by its ability to chemoattract human monocytes using a concentration range of 0.1-100 ng/ml.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: 98% by SDS-PAGE & HPLC analyses
• Length: 50
• Form: Lyophilized
• Molecular Weight: 6.0 kDa
• Shipping Conditions: Room Temperature