BD-3 Recombinant Protein

BD-3 Recombinant Protein

• Description: Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. Beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The Beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Beta-Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues. Recombinant Human BD-3 is a 5.1 kDa protein containing 45 amino acid residues.
• Synonyms: DEFB103A; BD-3; HBD3; HBP3; DEFB3; HBP-3; hBD-3; DEFB-3; DEFB103
• CAS Number: 9000-83-3
• NCBI Gene ID: 414325
• UniProt: P81534
• Accession Number: NP_061131.1
• Accession Number mRNA: NM_001081551.2
• Gene Location: 8p23.
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Bacteria, Mouse, Human, Virus
• Sequence: GIINTLQKYY CRVRGGRCAV LSCLPKEEQI GKCSTRGRKC CRRKK
• Detection Range: Exhibits antimicrobial activity against gram-positive bacteria S. aureus and gram-negative P. aeruginosa and E.coli.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Length: 45
• Form: Lyophilized
• Molecular Weight: 5.1 kDa
• Shipping Conditions: Room Temperature