BD-3 Recombinant Protein

BD-3 Recombinant Protein

• Description: Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant Murine BD-3 is a 4.6 kDa protein containing 41 amino acid residues.
• Synonyms: Beta-Defensin 3, DEFB3, DEFB103A
• CAS Number: 9000-83-3
• NCBI Gene ID: 27358
• UniProt: Q9WTL0
• Accession Number: NP_038784.1
• Accession Number mRNA: NM_013756.2
• Host: E. coli
• Origin Species: Mouse
• Species Reactivity: Mouse
• Sequence: KKINNPVSCL RKGGRCWNRC IGNTRQIGSC GVPFLKCCKR K
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses
• Length: 41
• Form: Lyophilized
• Molecular Weight: 4.6 kDa
• Shipping Conditions: Room Temperature