BD-1 Recombinant Protein

• Description:

  Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system.  The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds.  To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6.  β-defensins are expressed on some leukocytes and at epithelial surfaces.  In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells.  The β-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence.  β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant Murine BD-1 is a 4.1 kDa protein containing 37 amino acid residues.

• Synonyms:

  Beta-Defensin 1, DEFB1, HBD1

• NCBI Gene ID:

  13214

• UniProt:

  P56386

• Accession Number:

  NP_031869.1

• Accession Number mRNA:

  NM_007843.3

• Gene Location:

  8 A2; 8 10.35 cM

• Host:

  E. coli

• Origin Species:

  Mouse

• Species Reactivity:

  Mouse

• Sequence:

  DQYKCLQHGG FCLRSSCPSN TKLQGTCKPD KPNCCKS

• Endotoxin:

  < 0.1 ng/ug of protein (< 1 EU/ug)

• Purity:

  ≥ 98% by SDS-PAGE gel and HPLC analyses.

• Length:

  37

• Form:

  Lyophilized

• Molecular Weight:

  4.1 kDa

• Shipping Conditions:

  Room Temperature

• CAS Number:

  9000-83-3