BD-1 Recombinant Protein

BD-1 Recombinant Protein

• Description: Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system.  The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds.  To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6.  β-defensins are expressed on some leukocytes and at epithelial surfaces.  In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells.  The β-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence.  β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant Murine BD-1 is a 4.1 kDa protein containing 37 amino acid residues.
• Synonyms: Beta-Defensin 1, DEFB1, HBD1
• CAS Number: 9000-83-3
• NCBI Gene ID: 13214
• UniProt: P56386
• Accession Number: NP_031869.1
• Accession Number mRNA: NM_007843.3
• Gene Location: 8 A2; 8 10.35 cM
• Host: E. coli
• Origin Species: Mouse
• Species Reactivity: Mouse
• Sequence: DQYKCLQHGG FCLRSSCPSN TKLQGTCKPD KPNCCKS
• Endotoxin: < 0.1 ng/ug of protein (< 1 EU/ug)
• Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
• Length: 37
• Form: Lyophilized
• Molecular Weight: 4.1 kDa
• Shipping Conditions: Room Temperature