BD-5 Recombinant Protein

BD-5 Recombinant Protein

• Description: Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, six human beta-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The beta-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence. Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant Human BD-5 is a 57.8 kDa protein containing 51 amino acid residues.
• Synonyms: BD5, DEFB5, DEFB105a, Beta-Defensin 5
• CAS Number: 9000-83-3
• NCBI Gene ID: 245908
• UniProt: Q8NG35
• Accession Number: NP_689463.1
• Accession Number mRNA: NM_152250.2
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Human
• Sequence: GLDFSQPFPS GEFAVCESCK LGRGKCRKEC LENEKPDGNC RLNFLCCRQR I
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Length: 51
• Form: Lyophilized
• Molecular Weight: 5,8 kDa
• Shipping Conditions: Room Temperature