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RR-11a analog

CAT: 0804-HY-112205A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112205A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RR-11a analog is a potent and irreversible inhibitor of Schistosoma mansoni legumain, with an IC50 of 31 nM. RR-11a analog is an aza-Asn derivative and aza-peptide Michael acceptor[1][2].
CAS Number
685543-66-2
UNSPSC
12352005
Target
Legumain; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/RR-11a_analog.html
Purity
99.12
Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N[C@@H](C)C(N[C@@H](C)C(NN(CC(N)=O)C(/C=C/C(OCC)=O)=O)=O)=O)OCC1=CC=CC=C1
Molecular Formula
C22H29N5O8
Molecular Weight
491.49
References & Citations
[1]Götz MG, et al. Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. J Med Chem. 2008 May 8;51 (9) :2816-32.|[2]Ekici OD, et al. Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. J Med Chem. 2004 Apr 8;47 (8) :1889-92.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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