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LP-922056

CAT: 0804-HY-131034-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-131034-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LP-922056 is an orally active, highly potent Notum Pectinacetylesterase inhibitor with EC50s of 21 nM, 55 nM in human and mouse cellular assay, respectively. LP-922056 significantly increases midshaft femur cortical bone thickness in mice and rats[1][2].
CAS Number
1365060-22-5
UNSPSC
12352005
Target
Wnt
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/lp-922056.html
Concentration
10mM
Purity
99.63
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(O)CSC1=C2C(C(C3CC3)=C(Cl)S2)=NC=N1
Molecular Formula
C11H9ClN2O2S2
Molecular Weight
300.78
References & Citations
[1]James E Tarver Jr, et al. Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase. Bioorg Med Chem Lett. 2016 Mar 15;26 (6) :1525-1528.|[2]Robert Brommage, et al. NOTUM inhibition increases endocortical bone formation and bone strength. Bone Res. 2019 Jan 8;7:2.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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