MAC-545496

• Description :

  MAC-545496 is a nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR) . MAC-545496 displays strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM) . MAC-545496 is an antivirulence agent that reverses β-lactam resistance in Methicillin-resistant strains (MRSA) [1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Bacterial

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/mac-545496.html

• Purity :

  98.01

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  O=C(NC(NC1=NC=C(Cl)C=C1)=S)C2=CC=C(N3CCCCC3)C([N+]([O-])=O)=C2

• Molecular Formula :

  C18H18ClN5O3S

• Molecular Weight :

  419.89

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]El-Halfawy OM, et al. Discovery of an antivirulence compound that reverses β-lactam resistance in MRSA. Nat Chem Biol. 2019 Nov 25.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [838810-96-1]