MAC-545496

• Description:

  MAC-545496 is a nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR) . MAC-545496 displays strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM) . MAC-545496 is an antivirulence agent that reverses β-lactam resistance in Methicillin-resistant strains (MRSA) [1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/mac-545496.html

• Purity:

  98.01

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  O=C (NC (NC1=NC=C (Cl) C=C1) =S) C2=CC=C (N3CCCCC3) C ([N+] ([O-]) =O) =C2

• Molecular Formula:

  C18H18ClN5O3S

• Molecular Weight:

  419.89

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]El-Halfawy OM, et al. Discovery of an antivirulence compound that reverses β-lactam resistance in MRSA. Nat Chem Biol. 2019 Nov 25.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  838810-96-1