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MAC2-IN-1

CAT: 0804-HY-157150Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-157150Size:1 Each
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Description
MAC2-IN-1 (compound 14) is a potent and selective human adenylate cyclases (mACs) inhibitor with an IC50 of 4.45 μM. mAC2-IN-1 has low activity on mAC1 and mAC5[1].
UNSPSC
12352005
Target
Adenylate Cyclase
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mac2-in-1.html
Solubility
10 mM in DMSO
Smiles
CC(C)OC([C@H](NP(COCCN1C2=NC=NC(N)=C2C(C3=CC=CC(C(N4)=NOC4=O)=C3)=C1)(N[C@H](C(OC(C)C)=O)CC5=CC=CC=C5)=O)CC6=CC=CC=C6)=O
Molecular Formula
C41H47N8O8P
Molecular Weight
810.83
References & Citations
[1]Pavel Kraina, et al. Discovery of a potent and selective human AC2 inhibitor based on 7-deazapurine analogues of adefovir. Bioorg Med Chem. 2023 Nov 15:95:117508.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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