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YM-58483

CAT: 0013-GTR19171045-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19171045-01Size:5 mg
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Description
YM-58483 (BTP2) is a potent and selective CRAC channel inhibitor that effectively suppresses store-operated calcium entry (SOCE) and downstream calcium signaling. This tool compound is widely used in both in vitro and in vivo research to investigate immune cell activation, T-cell proliferation, and mast cell degranulation.
CAS Number
223499-30-7
Product Name Alternative
BTP2
Field of Research
Immunology & Inflammation
Purity
>98%
Bioactivity
CRAC channel blocker
Form
Powder
Solubility
Soluble in DMSO (up to 40 mg/ml)
Smiles
Cc1nnsc1C (=O) Nc1ccc (cc1) -n1nc (cc1C (F) (F) F) C (F) (F) F
Molecular Formula
C15H9F6N5OS
Molecular Weight
421.3
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
N-[4-[3,5-Bis (trifluoromethyl) -1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide

Chemical Information

4-methyl-4'-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-1,2,3-thiadiazole-5-carboxanilide

potently inhibits store-operated sustained Ca2+ influx and IL-2 production in T lymphocytes

CAS Number223499-30-7
PubChem CID2455
IUPAC NameN-[4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]phenyl]-4-methylthiadiazole-5-carboxamide
Molecular FormulaC15H9F6N5OS
Molecular Weight421.3
XLogP3.8
Topological Polar Surface Area101
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count11
Rotatable Bond Count3
Heavy Atom Count28
Formal Charge0
Complexity568
SMILES
CC1=C(SN=N1)C(=O)NC2=CC=C(C=C2)N3C(=CC(=N3)C(F)(F)F)C(F)(F)F
InChI
InChI=1S/C15H9F6N5OS/c1-7-12(28-25-23-7)13(27)22-8-2-4-9(5-3-8)26-11(15(19,20)21)6-10(24-26)14(16,17)18/h2-6H,1H3,(H,22,27)
InChIKey
XPRZIORDEVHURQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-methyl-4'-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-1,2,3-thiadiazole-5-carboxanilide
CAS: 223499-30-7
CID: 2455
Formula: C15H9F6N5OS
MW: 421.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight421.3
XLogP33.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count11
Rotatable Bond Count3
Exact Mass421.04320007
Monoisotopic Mass421.04320007
Topological Polar Surface Area101 Ų
Heavy Atom Count28
Formal Charge0
Complexity568
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
B7542-100YM 58483
bs-82613C-01YM-58483
A16346-2YM-58483 2mg
C13381-1gYM-58483 (BTP2)
A16346-100YM-58483 100mg
A16346-25YM-58483 25mg
A16346-5YM-58483 5mg
A16346-1YM-58483 1mg
HY-100831R-01YM-58483 (Standard)

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