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MNK8

CAT: 0804-HY-147187-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-147187-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MNK8 is a potent STAT3 (signal transducer and activator of transcription 3) inhibitor. MNK8 inhibits STAT3 activation and reduced its DNA binding ability. MNK8 shows good growth inhibition against hepatocellular carcinoma (HCC) cells. MNK8 induces apoptosis in HCC cells. MNK8 reduces prosurvival proteins expression and migration/invasion of HCC cells[1].
CAS Number
2055078-49-2
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; STAT; Survivin
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mnk8.html
Purity
99.76
Solubility
DMSO : 41.67 mg/mL (ultrasonic)
Smiles
O=C1N(C)C(C=C(C2=C3C=CC=CC3=CC=C2)N1)=O
Molecular Formula
C15H12N2O2
Molecular Weight
252.27
References & Citations
[1]Sajith AM, et al. Pyrimidine-2,4-dione targets STAT3 signaling pathway to induce cytotoxicity in hepatocellular carcinoma cells. Bioorg Med Chem Lett. 2021 Oct 15;50:128332.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; STAT3

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