MNK1/2-IN-7
CAT:
804-HY-163479
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
MNK1/2-IN-7
- CAS Number: 2548283-27-6
- UNSPSC Description: MNK1/2-IN-7 (compound 20j) is an orally available inhibitor of MNK1/2 with anticancer activity and hERG safety. MNK1/2-IN-7 also inhibits the phosphorylation of eIF4E, inhibiting the MNK/eIF4E signaling pathway and cancer cell proliferation. MNK1/2-IN-7 is synergistic with Ibrutinib (HY-109970)[1].
- Target Antigen: Eukaryotic Initiation Factor (eIF); MNK
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;MAPK/ERK Pathway
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/mnk1-2-in-7.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(C1=CC=C(C(C=C2)=NN3C2=NC=C3C4=CC5=C(O4)C=CC=C5)C=C1)N6CCC(CC6)N7CCCCC7
- Molecular Weight: 505.61
- References & Citations: [1]Yuan X, et al. Development of an Imidazopyridazine-Based MNK1/2 Inhibitor for the Treatment of Lymphoma[J]. Journal of Medicinal Chemistry, 2024.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported