MNK1/2-IN-6

MNK1/2-IN-6

• CAS Number: 2771087-94-4
• UNSPSC Description: MNK1/2-IN-6 is a potent and selective MNK1/2 inhibitor with IC50s of 2.3 nM and 3.4 nM for MNK1 and MNK2, respectively. MNK1/2-IN-6 induces apoptosis in a concentration-dependent manner[1].
• Target Antigen: Apoptosis; MNK
• Type: Reference compound
• Related Pathways: Apoptosis;MAPK/ERK Pathway
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/mnk1-2-in-6.html
• Solubility: 10 mM in DMSO
• Smiles: N[C@H]1CCCN(C1)C(C2=CC=C(C=C2)C3=NN4C(C5=CC=C6C=NC=CC6=C5)=CN=C4C=C3)=O
• Molecular Weight: 448.52
• References & Citations: [1]Bu H, et al. Design, synthesis and biological evaluation of imidazopyridazine derivatives containing isoquinoline group as potent MNK1/2 inhibitors. Bioorg Med Chem. 2021; 40:116186.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported