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Methoxamine (hydrochloride)

CAT: 0804-HY-B1298-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1298-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Methoxamine hydrochloride is a selective alpha1-adrenergic receptor agonist. Methoxamine hydrochloride causes vasoconstriction and increased peripheral vascular resistance[1][2]. Methoxamine hydrochloride significantly increased the overflow of ATP, ADP and AMP, but not adenosine, by a prazosin-sensitive mechanism in the rabbit pulmonary artery[3].
CAS Number
61-16-5
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Methoxamine_hydrochloride.html
Purity
99.32
Solubility
DMSO : 135 mg/mL (ultrasonic)
Smiles
OC(C(N)C)C1=CC(OC)=CC=C1OC.[H]Cl
Molecular Formula
C11H18ClNO3
Molecular Weight
247.72
Precautions
H315, H319, H335
References & Citations
[1]Sanders AB. The roles of methoxamine and norepinephrine in electromechanical dissociation. Ann Emerg Med. 1984;13 (9 Pt 2) :835-839. |[2]Chang KC. Hypertensive effects of methoxamine on arterial mechanics in rats: analysis based on exponentially tapered T-tube model. Eur J Pharmacol. 1998;350 (2-3) :195-202.|[3]Takeuchi K, et al. Methoxamine-induced release of endogenous ATP from rabbit pulmonary artery. Eur J Pharmacol. 1994;254 (3) :287-290.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched

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