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Methoxamine

CAT: 0804-HY-B1298ASize: 1 EachDry Ice: NoHazardous: No
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Description
Methoxamine is a selective alpha1-adrenergic receptor agonist. Methoxamine causes vasoconstriction and increased peripheral vascular resistance[1][2]. Methoxamine hydrochloride significantly increased the overflow of ATP, ADP and AMP, but not adenosine, by a prazosin-sensitive mechanism in the rabbit pulmonary artery[3].
CAS Number
390-28-3
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/methoxamine.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C(C(C(N)C)O)=C1)OC
Molecular Formula
C11H17NO3
Molecular Weight
211.26
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Sanders AB. The roles of methoxamine and norepinephrine in electromechanical dissociation. Ann Emerg Med. 1984;13 (9 Pt 2) :835-839.|[2]Chang KC. Hypertensive effects of methoxamine on arterial mechanics in rats: analysis based on exponentially tapered T-tube model. Eur J Pharmacol. 1998;350 (2-3) :195-202.|[3]Takeuchi K, et al. Methoxamine-induced release of endogenous ATP from rabbit pulmonary artery. Eur J Pharmacol. 1994;254 (3) :287-290.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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