Methoxyamine (hydrochloride)

• UNSPSC Description:

  Methoxyamine (O-Methylhydroxylamine) hydrochloride is an orally active and potent base excision repair (BER) inhibitor. Methoxyamine hydrochloride binds to 3’ hydroxyl groups that are left behind by 3-methylpurine-DNA glycosylase (MPG) following excision of the damaged base and thus inhibits BER activity. Methoxyamine hydrochloride binds directly to the apyrimidinic (AP) sites. Methoxyamine hydrochloride synergistically enhances the therapeutic efficacy of DNA-damaging agents[1][2].

• Target Antigen:

  Apoptosis; DNA/RNA Synthesis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/methoxyamine-hydrochloride.html

• Purity:

  98.0

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  NOC.[H]Cl

• Molecular Weight:

  83.52

• References & Citations:

  [1]Sameer Agnihotri, et al. ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents. Cancer Discov. 2014 Oct;4(10):1198-213.|[2]Samideh Khoei, et al. Effects of resveratrol and methoxyamine on the radiosensitivity of iododeoxyuridine in U87MG glioblastoma cell line. Exp Biol Med (Maywood). 2016 Jun;241(11):1229-36.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at room temperature, keep dry and cool

• Clinical Information:

  No Development Reported

• CAS Number:

  593-56-6